Effect of modernized collaborative care for depression on depressive symptoms and cardiovascular disease risk biomarkers: eIMPACT randomized controlled trial

Published in the journal Brain, Behavior and Immunity. Here is a link to the article.

Regenstrief Institute authors: Christopher M. Callahan, M.D., Sumedha Gupta, PhD, (affiliated scientist), Sujuan Gao, PhD, (affiliated scientist)

In a randomized controlled trial of 216 primary care patients with depression and elevated cardiovascular risk, a modernized collaborative care intervention significantly improved depressive symptoms compared to usual care. However, no changes were observed in cardiovascular disease (CVD) risk biomarkers. These results suggest that while early, tech-enabled depression treatment is effective for mental health, it may not be sufficient alone to reduce CVD risk—highlighting the need for alternative or additional interventions to address CVD in this population.

Authors:

Jesse C Stewart¹, Jay S Patel², Brittanny M Polanka³, Sujuan Gao⁴, John I Nurnberger⁵, Krysha L MacDonald⁶, Samir K Gupta⁷, Robert V Considine⁷, Richard J Kovacs⁸, Elizabeth A Vrany⁹, Jessica Berntson¹⁰, Loretta Hsueh¹¹, Aubrey L Shell¹², Bruce L Rollman¹³, Christopher M Callahan¹⁴

Affiliations

¹Department of Psychology, Indiana University-Purdue University Indianapolis (IUPUI), Indianapolis, IN, USA. Electronic address: jstew@iupui.edu.

²Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.

³Division Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.

⁴Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA.

⁵Department of Psychiatry and Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.

⁶Sandra Eskenazi Mental Health Center, Eskenazi Health, Indianapolis, IN, USA.

⁷Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

⁸Division of Cardiovascular Disease, Indiana University School of Medicine, Indianapolis, IN, USA.

⁹Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.

¹⁰Dr. Jessica Berntson Inc., Coquitlam, BC, Canada.

¹¹Department of Psychology, University of Illinois Chicago, Chicago, IL, USA.

¹²Department of Psychology, Indiana University-Purdue University Indianapolis (IUPUI), Indianapolis, IN, USA.

¹³Center for Behavioral Health, Media, and Technology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

¹⁴Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; Sandra Eskenazi Center for Brain Care Innovation, Eskenazi Health, Indianapolis, IN, USA.