Influence
March 21, 2022

Revolutionizing research through pragmatic trials

Regenstrief Institute Research Scientist Kathleen Unroe, M.D., MHA, M.S., is at the forefront of the next generation of research methodology: pragmatic trials. Pragmatic trials are designed to evaluate the effectiveness of interventions in real-life practice, speeding up the time from discovery to implementation.  

Dr. Unroe, along with Regenstrief faculty member Susan Hickman, PhD, is leading one of few pragmatic trials funded by the National Institute on Aging. The APPROACHES (Aligning Patient Preferences – a Role Offering Alzheimer’s patients, Caregivers, and Healthcare providers Education and Support) trial is being conducted in 150 nursing homes, testing an intervention to support advance care planning.  

She is also part of the IMPACT Collaboratory, a research incubator to develop pragmatic trials and train researchers to design and execute them.  

In 2021, Dr. Unroe spoke at a conference about pragmatic trials in long-term care facilities. The event identified priorities and best practices for trials taking place in these real-world settings. 

Dr. Unroe says she is excited about the potential of pragmatic trials for creating solutions as well as creating partnerships between researchers and healthcare systems.  

In addition to being a research scientist in the IU Center for Aging Research at Regenstrief Institute, Dr. Unroe is an associate professor at the IU School of Medicine and a practicing geriatrician. 

  • Kathleen Unroe

Related News

Randall Grout, MD

Widespread diaper need poses serious health threats to families

Shortages impact 41 percent of infants, underscoring need for urgent action Diapers are a basic hygiene necessity for infants

Shaun Grannis, M.D., M.S.

Effectiveness of 2023–2024 COVID-19 vaccines in children in the U.S.

Published in Pediatrics. Here is a link to the article. Regenstrief Institute author: Shaun Grannis, M.D., M.S., Brian Dixon,

Chris Harle, PhD

Supporting electronic health record data usage in research for teams with varying data science and clinical knowledge: a food service analogy approach

Published in the Journal of the American Medical Informatics Association: JAMIA. Here is a link to the article. Regenstrief

Predictive model, comprehensive data identify risk factors for amputation and death among patients with chronic wounds

Predictive model, comprehensive data identify risk factors for amputation and death among patients with chronic wounds

Findings from Regenstrief Institute’s Chronic Wound Registry may help clinicians and patients make informed decisions and improve outcomes  Chronic wounds affect