Risk factors for dementia in older intensive care unit (ICU) survivors

Published in the journal Alzheimer’s & Dementia. Here is a link to the article.

Regenstrief Institute authors: Sikandar Khan, D.O., M.S., Malaz Boustani, M.D., MPH, Babar Khan, M.D., M.S., Sujuan Gao, PhD, (affiliated scientist)

In a study of over 3,000 ICU patients aged 50 and older, post-ICU stroke and depression were significantly associated with increased risk of developing dementia. Unlike typical Alzheimer’s disease risk factors, cardiovascular risks were not linked to post-ICU dementia. These findings highlight the need for future interventions targeting stroke and depression to reduce dementia incidence in ICU survivors.

Authors:
Sophia Wang^1,2, Anthony J Perkins³, Rosalyn Chi⁴, Brandon A Yates^5,6, Sikandar H Khan^4,6, Sujuan Gao^2,3, Malaz Boustani^4,6,7,8,9, Babar A Khan^4,6,7,8

Affiliations
¹Department of Psychiatry, IU Health Neuroscience Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.
²Indiana Alzheimer’s Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.
³Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, USA.
⁴Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
⁵Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, Indiana, USA.
⁶IU Center of Aging Research, Regenstrief Institute, Indianapolis, Indiana, USA.
⁷Indiana University Center of Health Innovation and Implementation Science, Indianapolis, Indiana, USA.
⁸Sandra Eskenazi Center for Brain Care Innovation, Eskenazi Hospital, Indianapolis, Indiana, USA.
⁹Division of Geriatrics and General Internal Medicine, Department of Internal Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.