Influence
August 1, 2025

Symptom Burden in Adolescents and Young Adults With Cancer

Kurt Kroenke, MD

Published in the JAMA Network Open. Here is a link to the article.

Regenstrief Institute authors: Kurt Kroenke, M.D.

This study looked at how symptoms affect adolescents and young adults ages 18 to 39 with cancer compared to older adults. Using data from the E2C2 trial, researchers analyzed six symptoms patients reported: trouble sleeping, pain, limited physical function, anxiety, depression, and fatigue. Younger adults with cancer were more often female, single, employed, and college educated, and more likely to live in cities. They were also more likely to have sarcoma or brain cancers and less likely to have cancer that had spread. The goal was to understand which factors are linked to more severe symptoms so care teams can better support younger cancer patients.

Authors: 

Michael H Storandt 1Zhaohui Jin 1Kathryn J Ruddy 1Deirdre R Pachman 1Oudom Kour 1Veronica Grzegorczyk 1Kurt Kroenke 2Joan M Griffin 1Jessica D Austin 3Sandra A Mitchell 4Ashley Wilder Smith 4Shawna Ehlers 1Linda L Chlan 1Ewan K Cobran 1Jacob R Greenmyer 1Wendy A Allen-Rhoades 1Qian Shi 1Andrea L Cheville 1

Affiliations

1Mayo Clinic, Rochester, Minnesota.

2Indiana University School of Medicine, Indianapolis.

3Mayo Clinic, Phoenix, Arizona.

4National Cancer Institute, Bethesda, Maryland.

Related News

Arthur Owora, PhD

Machine learning tool improves pediatricians’ ability to identify children at risk for persistent asthma 

Pilot randomized trial finds EHR-integrated decision support improved clinicians’ prediction of school-age asthma  A machine learning tool that analyzes

Health First Indiana generated estimated $742.6 million in savings through key public health services

An analysis from the Regenstrief Institute found that Health First Indiana (HFI), the state’s landmark public health funding initiative,

Office of Strategic Innovation helps connect startups with research expertise

Moving healthcare innovations from promising ideas to real-world impact requires collaboration between researchers, entrepreneurs, healthcare organizations and industry partners.

e-star logo

First E-STAR annual report offers unprecedented view of early access to kidney transplantation

National registry data reveal opportunities to improve referral, evaluation and waitlisting for patients with kidney failure Chronic kidney disease