Influence
August 1, 2025

Symptom Burden in Adolescents and Young Adults With Cancer

Kurt Kroenke, MD

Published in the JAMA Network Open. Here is a link to the article.

Regenstrief Institute authors: Kurt Kroenke, M.D.

This study looked at how symptoms affect adolescents and young adults ages 18 to 39 with cancer compared to older adults. Using data from the E2C2 trial, researchers analyzed six symptoms patients reported: trouble sleeping, pain, limited physical function, anxiety, depression, and fatigue. Younger adults with cancer were more often female, single, employed, and college educated, and more likely to live in cities. They were also more likely to have sarcoma or brain cancers and less likely to have cancer that had spread. The goal was to understand which factors are linked to more severe symptoms so care teams can better support younger cancer patients.

Authors: 

Michael H Storandt 1, Zhaohui Jin 1, Kathryn J Ruddy 1, Deirdre R Pachman 1, Oudom Kour 1, Veronica Grzegorczyk 1, Kurt Kroenke 2, Joan M Griffin 1, Jessica D Austin 3, Sandra A Mitchell 4, Ashley Wilder Smith 4, Shawna Ehlers 1, Linda L Chlan 1, Ewan K Cobran 1, Jacob R Greenmyer 1, Wendy A Allen-Rhoades 1, Qian Shi 1, Andrea L Cheville 1

Affiliations

1Mayo Clinic, Rochester, Minnesota.

2Indiana University School of Medicine, Indianapolis.

3Mayo Clinic, Phoenix, Arizona.

4National Cancer Institute, Bethesda, Maryland.

Related News

image of a doctor consulting with a patient

Scalable approach could improve early detection of cognitive impairment in primary care

Regenstrief-led study evaluates how existing health data and patient-reported information could help clinicians identify individuals who need further assessmentEarly

Christopher Callahan, MD

Regenstrief Institute scientist named next president and CEO of Regenstrief Foundation 

Longtime Regenstrief investigator and former IU Center for Aging Research director will assume Foundation leadership in summer 2027.  Christopher

Rachel Patzer, PhD, MPH

Building trust in healthcare AI through data and evidence

As artificial intelligence rapidly transforms healthcare, innovation alone is not enough. Health systems need evidence that AI tools are

doctor using electronic health record

Data expertise helps researchers understand how clinical tools are used in real-world care

Regenstrief Data Services (RDS) provided critical health data and specialized expertise to support research examining clinical decision-support use across