Regenstrief scientists working on some of the first electronic health records in the early 1970s.

Driving the Future of Healthcare Together

For more than five decades, Regenstrief Insitute has turned data into better care.

We helped develop the first operational electronic medical record, launched one of the nation’s earliest health information exchanges, created the GUIDE model for dementia, and developed LOINC, the global standard for clinical observation codes.

Applied Evidence Generation

Regenstrief partners with organizations to turn real-world care data into rigorous evidence.

image of doctor interacting with electronic health record

Clinical AI/ML

Evaluating clinical AI performance and adoption.

Questions We Help Answer

  • How generalizable is the AI model across populations?
  • How does model performance compare to clinician judgment?
  • How does the tool integrate into clinician workflow?
  • What produces friction or creates alert fatigue?
  • What safety, bias, or drift risks exist?
  • How does downstream performance change over time?

Common Partners: Clinical AI/ML companies | Health systems deploying AI at scale

Capsules on a reflective surface with digital graphs in the background. Healthcare and technology merge in a modern depiction of medicine. Volatility of medical companies on the stock market..

Real-World Evidence

Generating decision-grade evidence beyond clinical trials.

Questions We Help Answer

  • How do real-world treatment patterns compare to trials?
  • Where are diagnostic, referral, or treatment delays happening?
  • How do comorbidities or care transitions influence safety?
  • What are heterogeneous treatment effects within groups?
  • How can NLP, phenotyping, and linked data advance population identification and early detection of risk?

Common Partners: Life science companies

What We Offer

Regenstrief brings one of the richest longitudinal health data ecosystems in the U.S. to applied research and evidence generation, anchored by the Indiana Network for Patient Care (INPC) and supported by Regenstrief Data Services (RDS).

graphic numerals showing the amount of unique patients, coded results, clinical encounters, and unstructured text reports exist in the INPC.Core Capabilities

  • Technology Innovation: Pioneering clinical data systems that streamline healthcare delivery
  • Population-Level Clinical Repository: Leading data integration, provider connectivity, and privacy-preserving record linkage
  • Cohort Construction & Phenotyping: Sophisticated data modeling to support thousands of research initiatives
  • AI & Machine Learning Support: Large-scale, high-quality datasets for training and testing AI models
  • Data Transformation: Converting real-world healthcare data into usable, actionable intelligence
  • Domain Experts: National leaders across renal, oncology, and aging domains

Collaborative Impact

Should AI-based trial matching be scaled safely a large health system?
Should AI-based trial matching be scaled safely
a large health system?

Triomics × IU Health oncology pilot

Adoption & Scale Decisions
Should AI-based trial matching be scaled safely
a large health system?
Generating Evidence Across the Full Arc of Disease
Generating Evidence Across the Full Arc of Disease

Regenstrief × Merck

Real-World Evidence • Real-World Data • Life Sciences

Generating Evidence Across the Full Arc of Disease

The Q → A Sprint

Question to Answer Sprints move uncertainty to evidence.

Collaborations range from multi-month sprints to longer-term real-world evidence studies. Outputs range from peer-reviewed studies and AI/ML monitoring frameworks to clinical decision support tools and executive guidance.

graphic showing the progression of the Q>A sprint process

Office of Strategic Innovation

 

Regenstrief’s Office of Strategic Innovation (OSI) coordinates applied research collaborations
with industry partners who need rigorous evidence to move from insight to action.

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