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Serena Guo, MD, PhD

Jingchuan Serena Guo, MD, PhD

Initiatives

Informatics

Research Scientist, Clem McDonald Center for Biomedical Informatics, Regenstrief Institute
Associate Professor, Department of Pharmacy Practice, Purdue University
Faculty Liaison, Regenstrief Data Services

Serena Guo conducts research in pharmacoepidemiology and pharmacoinformatics, primarily focused on cardiometabolic diseases, neurodegenerative conditions (e.g., dementia) and cancer, with the goal of promoting precision therapeutics. Her research draws on large real-world data (e.g., electronic health records, insurance claims data) and advanced analytics (e.g., AI/machine learning, causal-principled modeling) to: 1) assess comparative effectiveness/safety and heterogeneous treatment effects (HTEs) of treatments and interventions, and 2) develop intelligent clinical decision support tools to be integrated into clinical care.

Dr. Guo has published over 150 peer-reviewed manuscripts. Several articles have been published in top-tier journals, including Annals of Internal Medicine, Nature Communications, and JAMA Neurology, and featured in media outlets, including the Washington Post, NPR, and CNN. Her research programs have been funded by the NIDDK, NIA, NIMHD, CDC, the PhRMA Foundation and pharmaceutical collaborators.