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Sikandar Khan, DO, MS
- Research Scientist, Indiana University Center for Aging Research at Regenstrief Institute
- Co-Program Director, COVID-19 Recovery Program for Older Adults, IU Center for Aging Research, Regenstrief Institute
- Assistant Professor of Medicine, Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine
- Director, Indiana University Health Intensive Care Unit (ICU) Survivor Center, Indiana University School of Medicine
Dr. Khan’s research is focused on the nexus of acute respiratory failure, delirium in the intensive care unit (ICU), and cognitive and physical function outcomes in critically ill older adults. As of 2022, Dr. Khan is funded by the National Institutes of Health’s (NIH) National Institute on Aging (NIA) Paul Beeson Emerging Leaders Career Development Award to study the role of oxidative stress in critical illness, ICU delirium and post-ICU aging. His research activities to date include measurement of delirium duration and severity, identification of delirium risk factors, exploring delirium’s association with dementia through peripheral blood-based biomarkers and testing novel non-pharmacological interventions to mitigate delirium in the ICU. Dr. Khan’s clinical expertise is focused on maximizing the cognitive, physical, mental health and quality of life recovery for survivors of critical illness.
Highlighted Publications
Khan SH, Lindroth H, Perkins AJ, Jamil Y, Wang S, Roberts S, Farber M, Rahman O, Gao S, Marcantonio ER, Boustani M, Machado R, Khan BA. Delirium Incidence, Duration, and Severity in Critically Ill Patients With Coronavirus Disease 2019. Crit Care Explor. 2020 Nov 25;2(12):e0290. doi: 10.1097/CCE.0000000000000290.
Khan SH, Lindroth H, Jawed Y, Wang S, Nasser J, Seyffert S, Naqvi K, Perkins AJ, Gao S, Kesler K, Khan B. Serum Biomarkers in Postoperative Delirium after Esophagectomy. Ann Thorac Surg. 2021 Mar 24:S0003-4975(21)00558-0. doi: 10.1016/j.athoracsur.2021.03.035.
Khan SH, Lindroth H, Hendrie K, Wang S, Imran S, Perkins AJ, Gao S, Vahidy FS, Boustani M, Khan BA. Time trends of delirium rates in the intensive care unit. Heart Lung. 2020 Mar 25;. doi: 10.1016/j.hrtlng.2020.03.006.
Khan SH, Xu C, Wang S, Gao S, Lasiter S, Kesler K, Khan BA. Effect of Delirium on Physical Function in Noncardiac Thoracic Surgery Patients. Am J Crit Care. 2020 Mar 1;29(2):e39-e43. doi: 10.4037/ajcc2020579.
Khan SH, Xu C, Purpura R, Durrani S, Lindroth H, Wang S, Gao S, Heiderscheit A, Chlan L, Boustani M, Khan BA. Decreasing Delirium Through Music: A Randomized Pilot Trial. Am J Crit Care. 2020 Mar 1;29(2):e31-e38. doi: 10.4037/ajcc2020175.
Khan SH, Manchanda S, Sigua NL, Green E, Mpofu PB, Hui S, Khan BA. Hospital outcomes in non-surgical patients identified at risk for OSA. Heart Lung. 2020 Mar-Apr;49(2):112-116. doi: 10.1016/j.hrtlng.2019.12.001.
Fuchita M, Khan SH, Perkins AJ, Gao S, Wang S, Kesler KA, Khan BA. Perioperative Risk Factors for Postoperative Delirium in Patients Undergoing Esophagectomy. Ann Thorac Surg. 2019 Jul;108(1):190-195. doi: 10.1016/j.athoracsur.2019.01.040.
Khan SH, Devnani R, LaPradd M, Landrigan M, Gray A, Kelley A, Eckert GJ, Li X, Khan BA. Age of transfused red blood cells and health outcomes in two surgical cohorts. Heart Lung. 2019 Mar-Apr;48(2):131-137. doi: 10.1016/j.hrtlng.2018.08.012.
Khan SH, Kitsis M, Golovyan D, Wang S, Chlan LL, Boustani M, Khan BA. Effects of music intervention on inflammatory markers in critically ill and post-operative patients: A systematic review of the literature. Heart Lung. 2018 Sep-Oct;47(5):489-496. doi: 10.1016/j.hrtlng.2018.05.015.
Twigg HL 3rd, Khan SH, Perkins AJ, Roberts S, Sears C, Rahman O, Smith JP, Kapoor R, Farber MO, Ellender T, Carlos G, Gilroy G, Buckley J, Bosslet G, Machado R, Gao S, Khan BA. Mortality Rates in a Diverse Cohort of Mechanically Ventilated Patients With Novel Coronavirus in the Urban Midwest. Crit Care Explor. 2020 Aug 20;2(8):e0187. doi: 10.1097/CCE.0000000000000187.
Lindroth H, Khan BA, Carpenter JS, Gao S, Perkins AJ, Khan SH, Wang S, Jones RN, Boustani MA. Delirium Severity Trajectories and Outcomes in ICU Patients: Defining a Dynamic Symptom Phenotype. Ann Am Thorac Soc. 2020 May 8;. doi: 10.1513/AnnalsATS.201910-764OC.
Lindroth H, Mohanty S, Ortiz D, Gao S, Perkins AJ, Khan SH, Boustani MA, Khan BA. Dynamic Delirium Severity Trajectories and Their Association With 2-Year Healthcare Utilization and Mortality Outcomes. Crit Care Explor. 2021 Sep 10;3(9):e0524. doi: 10.1097/CCE.0000000000000524. PMID: 34589712; PMCID: PMC8437216.
Khan BA, Perkins AJ, Prasad NK, Shekhar A, Campbell NL, Gao S, Wang S, Khan SH, Marcantonio, ER, Twigg HL, Boustani MA. Biomarkers of Delirium Duration and Delirium Severity in the ICU. Crit Care Med. 2020;48(3). doi: 10.1097/CCM.0000000000004139
Current Research Projects
Indiana COVID-19 Recovery Program for Older Adults
(Regenstrief Institute, PI: Khan, S.)
The goal of this study is to establish the IRecovery Program as a state-wide discovery-to-delivery clinical research laboratory capable of cultivating transdisciplinary scientific activities with a focus on optimizing cognitive, functional, and psychologic independence among COVID-19 survivors.
Inflammatory Biomarkers and Clinical Outcomes in Critically Ill Older Adults with COVID-19
(Regenstrief Institute, PI: Khan, S.)
The goal of this study is to measure the association among daily inflammatory markers, delirium and clinical outcomes including length of stay, mortality and institutionalization, in critically ill COVID-19 patients.