Titus K. Schleyer, DMD, PhD, FACMI, FAMIA

Contact :

schleyer@regenstrief.org

Information technology and informatics are essential to help healthcare chart a viable path forward. The Regenstrief Institute offers the opportunity to work at the intersection of multiple disciplines to pursue this objective.

Initiatives

Informatics

Research Scientist, Clem McDonald Center for Biomedical Informatics, Regenstrief Institute
Program Director, Learning Health Informatics Program, Regenstrief Institute
Professor of Biomedical Informatics, Indiana University School of Medicine

Dr. Titus Schleyer leads the Indiana Learning Health System Initiative, which is focused on using everyday patient care data to improve the health and healthcare of people in Indiana. One of his award-winning projects helps emergency clinicians at IU Health obtain relevant information about their patients from Indiana’s health information exchange more efficiently and effectively than previously possible.

Another project, Dr. Schleyer and his team are analyzing data from Marion County to find out which factors are predictive of opioid overdoses and deaths.

An award-winning educator, Dr. Schleyer is focused on educating the next generation of biomedical informaticians. He co-directs the National Library of Medicine funded Indiana Public & Population Health Informatics Fellowship. He also mentors fellows in three other training programs.

Dr. Schleyer holds DMD and PhD degrees from the Goethe University in Frankfurt, Germany, and DMD and MBA degrees from Temple University in Philadelphia, Pennsylvania.

Featured Projects

Indiana Learning Health System Initiative (ILHSI)

(Regenstrief Institute, IU School of Medicine, Lilly Endowment, Inc.)

Role: Co-Principal Investigator

The ILHSI has the mission improve health by using patient and other information to transform healthcare through continued innovation and evaluation. It envisions a world where a cycle of data analysis, system improvements, and innovation sustains improvement in healthcare delivery and outcomes for all – clinicians, patients, caregivers, researchers, and educators.

Health Dart

(AHRQ, Lilly Endowment, Inc.)

Role: Principal Investigator

Health Dart directly and seamlessly integrates data from the INPC into Cerner to facilitate clinician access to relevant external information. It has been proven to increase HIE information use in all 15 IU Health emergency departments.

Hitachi diabetes predictive algorithm

(Hitachi, Ltd., Indiana CTSI Clinical and Translational Sciences Award, Lilly Endowment, Inc.)

Role: Investigator

The project focused on combining multiple data sources to generate an algorithm to support clinical decision-making for type 2 diabetes. A paper entitled “Predicting pharmacotherapeutic outcomes for type 2 diabetes: An evaluation of three approaches to leveraging electronic health record data from multiple sources ” is in print with the Journal of Biomedical Informatics.

Advanced Analytics for IU's Addictions Grand Challenge (A2AGC)

(Indiana University)

Role: Principal Investigator

The aim of this project is to help researchers and public health practitioners understand the trajectory of individuals towards substance use disorder, overdose, and overdose death.

Highlighted Publications

May 2022

Predicting pharmacotherapeutic outcomes for type 2 diabetes: An evaluation of three approaches to leveraging electronic health record data from multiple sources

Publication: Journal of Biomedical Informatics

doi: 10.1016/j.jbi.2022.104001

Authors: Tarumi S, Takeuchi W, Qi R, Ning X, Ruppert L, Ban H, Robertson DH, Schleyer TK, Kawamoto, K

Jul 2021

The Indiana Learning Health System Initiative: Early experience developing a collaborative, regional learning health system

Publication: Learning Health Systems

doi: 10.1002/lrh2.10281

Authors: Schleyer T, Williams L, Gottlieb J, Weaver C, Saysana M, Azar J, Sadowski J, Frederick C, Hui S, Kara A, Ruppert L

May 2021

Use, Impact, Weaknesses, and Advanced Features of Search Functions for clinical use in electronic health records: A scoping review

Publication: Applied Clinical Informatics

doi: 10.1055/s-0041-1730033

Authors: Hill JR, Visweswaran S, Ning X, Schleyer TK

Jan 2021

Hybrid Collaborative filtering methods for recommending search terms to clinicians

Publication: Journal of Biomedical Informatics

doi: 10.1016/j.jbi.2020.103635

Authors: Ren Z, Peng B, Schleyer T, Ning X

Nov 17, 2020

Risk factors for bleeding and clinical ineffectiveness associated with clopidogrel therapy: A comprehensive meta‐analysis

Publication: Clinical and Translational Science

doi: 10.1111/cts.12926

Authors: Nguyen K, Eadon M, Yoo R, Milway E, Kenneally A, Fekete K, Oh H, Duong K, Whipple E, Schleyer T

Oct 22, 2020

Does Nonsurgical Periodontal Treatment Improve Systemic Health?

Publication: Journal of Dental Research

doi: 10.1177/0022034520965958

Authors: Taylor HL, Rahurkar S, Treat TJ, Thyvalikakath TP, Schleyer TK

Aug 17, 2020

The National COVID Cohort Collaborative (N3C): Rationale, Design, Infrastructure, and Deployment

Publication: Journal of the American Medical Informatics Association

doi: 10.1093/jamia/ocaa196

Authors: Haendel MA, Chute CG, Kenneth G

Aug 20, 2020

Structuring, reuse and analysis of electronic dental data using the Oral Health and Disease Ontology

Publication: Journal of Biomedical Semantics

doi: 10.1186/s13326-020-00222-0

Authors: Duncan WD, Thyvalikakath T, Haendel M, Torniai C, Hernandez P, Song M, Acharya A, Caplan DJ, Schleyer T, Ruttenberg A

Jan 7, 2019

Predicting the early risk of chronic kidney disease in patients with diabetes using real-world data

Publication: Nature Medicine

doi: 10.1038/s41591-018-0239-8

Authors: Ravizza S, Huschto T, Adamov A, Böhm L, Büsser A, Flöther FF, Hinzmann R, König H, McAhren S, Robertson D, Schleyer T, Schneidinger B, Petrich W

May 2019

Quantifying unmet need in statin-treated hyperlipidemia patients and the potential benefit of further LDL-C reduction through an EHR-based, retrospective cohort study

Publication: Journal of Managed Care & Specialty Pharmacy

doi: 10.18553/jmcp.2019.25.5.544

Authors: Schleyer T, Hui S, Wang J, Zhang Z, Knapp K, Baker J, Chase M, Boggs R, Jr. Simpson RJ

Sep 2018

A comprehensive review and meta-analysis of risk factors for statin-induced myopathy

Publication: European Journal of Clinical Pharmacology

doi: 10.1007/s00228-018-2482-9

Authors: Nguyen K, Li L, Lu D, Yazdanparast A, Wang L, Kreutz R, Whipple EC, Schleyer TK

Dec 13, 2016

Getting from here to there: Health IT needs for population health

Publication: American Journal of Managed Care

PMID: 27982666

Authors: Vest JR, Harle CA, Schleyer T, Dixon BE, Grannis SJ, Halverson PK, Menachemi N

In The News

Influence

Featured Fellowship

People

NewsFactors influencing participation of Black and White Americans in Alzheimer’s disease biomarker research

NewsMulti-state study reports COVID-19 mRNA vaccines protective during Omicron BA.4/BA.5 predominance

NewsIBJ Honors Regenstrief research scientist with Heath Care Hero Award

NewsLOINC 2.74 Release Webinar scheduled for spring 2023

NewsLOINC continues facilitating health data interoperability with biannual issuance of new concepts

Factors influencing participation of Black and White...