Babar Khan, M.D., M.S., discusses whether commonly used blood pressure medications have protective qualities against delirium in the ICU.
Delirium is a manifestation of brain failure. We thought that maybe that group, if they are on chronic medications for blood pressure, particularly that group of medications with neuroprotective effects, may be less prone to developing delirium once they admit to the ICU. But we found that even with exposure to ACE inhibitors or angiotensin receptor blockers on a long-term basis did not prevent from development of ICU delirium in patients who were critically ill and admitted to our local ICUs.
Science is incremental, and these negative studies support or refute our hypothesis that allows us to build better studies and better trials for the future.