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Christopher M. Callahan, MD

Christopher M. Callahan, MD

  • Research Scientist, Indiana University Center for Aging Research at Regenstrief Institute
  • Professor of Medicine, Indiana University School of Medicine
  • Chief Research and Development Officer, Eskenazi Health

Dr. Chris Callahan has 25 years of experience in studying clinical interventions and new models of care designed to improve outcomes for older adults. His work began with a focus on late-life depression and dementia and developed into research on multi-morbidity and fragmentation of care. He joined the Regenstrief Institute in 1988.

Dr. Callahan’s research experience also includes the use of large clinical and survey research databases, including Medicare and Medicaid claims data, to conduct clinical epidemiologic studies. He has used these observational data to design and conduct randomized controlled clinical trials of complex interventions and has translated these interventions into real-world programs. He has focused particularly on vulnerable elders who are typically low-income, minority, disabled, and dual-eligible.

He is the founding and former director of the IU Center for Aging Research at Regenstrief Institute. He continues a long track record of successful mentoring for junior faculty, both locally and nationally. Along with Alexia Torke, MD, he co-leads the Training Core for the NIA-funded IMPACT Collaboratory. The Training Core seeks to grow the next generation of US researchers conducting embedded pragmatic clinical trials among persons living with dementia and their caregivers. Dr. Callahan is the Chief Research and Development Officer at Eskenazi Health. In this role, he and his team are redesigning the research, informatics, and data analytics infrastructure to better support improvements in quality, efficiency, and patient experience.

“We, both clinicians and patients – can do a better job of preventing harm and maintaining the brain as it ages.”

Highlighted Publications

Callahan CM, Hui SL, Nienaber NA, Musick BS, Tierney WM. Longitudinal study of depression and health services use among elderly primary care patients. J Am Geriatr Soc. 1994 Aug;42(8):833-8. PubMed PMID: 8046192

Callahan CM, Hendrie HC, Dittus RS, Brater DC, Hui SL, Tierney WM. Improving treatment of late life depression in primary care: a randomized clinical trial. J Am Geriatr Soc. 1994 Aug;42(8):839-46. PubMed PMID: 8046193

Unützer J, Katon W, Callahan CM, Williams JW Jr, Hunkeler E, Harpole L, Hoffing M, Della Penna RD, Noël PH, Lin EH, Areán PA, Hegel MT, Tang L, Belin TR, Oishi S, Langston C. Collaborative care management of late-life depression in the primary care setting: a randomized controlled trial. JAMA. 2002 Dec 11;288(22):2836-45. PubMed PMID: 12472325

Callahan CM, Kroenke K, Counsell SR, Hendrie HC, Perkins AJ, Katon W, Noel PH, Harpole L, Hunkeler EM, Unützer J. Treatment of depression improves physical functioning in older adults. J Am Geriatr Soc. 2005 Mar;53(3):367-73. PubMed PMID: 15743276

Callahan CM, Boustani MA, Unverzagt FW, Austrom MG, Damush TM, Perkins AJ, Fultz BA, Hui SL, Counsell SR, Hendrie HC. Effectiveness of collaborative care for older adults with Alzheimer disease in primary care: a randomized controlled trial. JAMA. 2006 May 10;295(18):2148-57. PubMed PMID: 16684985

Callahan CM, Arling G, Tu W, Rosenman MB, Counsell SR, Stump TE, Hendrie HC. Transitions in care for older adults with and without dementia. J Am Geriatr Soc. 2012 May;60(5):813-20. PubMed PMID: 22587849; PubMed Central PMCID: PMC3354737

Callahan CM, Boustani MA, Schmid AA, LaMantia MA, Austrom MG, Miller DK, Gao S, Ferguson DY, Lane KA, Hendrie HC. Targeting Functional Decline in Alzheimer Disease: A Randomized Trial. Ann Intern Med. 2017 Feb 7;166(3):164-171. PubMed PMID: 27893087

Campbell NL, Perkins AJ, Gao S, Skaar TC, Li L, Hendrie HC, Fowler N, Callahan CM, Boustani MA. Adherence and Tolerability of Alzheimer’s Disease Medications: A Pragmatic Randomized Trial. J Am Geriatr Soc. 2017 Jul;65(7):1497-1504. PubMed PMID: 28295141

Callahan CM, Arling G, Tu W, Rosenman MB, Counsell SR, Stump TE, Hendrie HC. Transitions in care for older adults with and without dementia. J Am Geriatr Soc. 2012 May;60(5):813-20. doi: 10.1111/j.1532-5415.2012.03905.x. PMID: 22587849; PMCID: PMC3354737

Callahan CM, Apostolova LG, Gao S, Risacher SL, Case J, Saykin AJ, Lane KA, Swinford CG, Yoder MC. Novel Markers of Angiogenesis in the Setting of Cognitive Impairment and Dementia. J Alzheimers Dis. 2020;75(3):959-969. doi:10.3233/JAD-191293. PMID: 32390626; PMCID: PMC8351220

Callahan CM. Moving Toward Fully Blended Collaborative Care: Integrating Medical and Social Care. JAMA Intern Med. 2021 Oct 1;181(10):1380-1382. doi: 10.1001/jamainternmed.2021.4993. PMID: 34459854

Campbell NL, Holden RJ, Tang Q, Boustani MA, Teal E, Hillstrom J, Tu W, Clark DO, Callahan CM. Multicomponent behavioral intervention to reduce exposure to anticholinergics in primary care older adults. J Am Geriatr Soc. 2021 Jun;69(6):1490-1499. doi: 10.1111/jgs.17121. Epub 2021 Mar 26. PMID: 33772749

Current Research Projects

MIND Food and Speed of Processing Training in Older Adults with Low Education, The MINDSpeed Alzheimer’s Disease Prevention Pilot Trial
(R01 – NIA, PI: Clark) (2018-2022)
This project will test in a pilot randomized controlled trial the effects of “MIND” foods and speed of processing training on cognitive reserve in older adults with low education. Role: Co-Investigator

NIA IMPACT Collaboratory
(U54- NIA) (2019-2024)
The National Institute on Aging (NIA) IMbedded Pragmatic Alzheimer’s Disease (AD) and AD-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory serves as a national resource for the conduct of ePCTs to improve the care of PLWD in partnership with the healthcare systems that serve them. Role: Training Core Co-Lead

Social Determinants of Health
(Eskenazi Health Foundation, PI: Callahan) (2019-2022)
Eskenazi Health and its philanthropic and community partners have invested in a systematic expansion of efforts to integrate medical care with social care. This project builds the organizational, environmental and technological foundation for this work. Role: Co-Investigator