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Paul R. Dexter, MD

Paul R. Dexter, MD

  • Research Scientist, Clem McDonald Center for Biomedical Informatics, Regenstrief Institute
  • Associate Professor of Clinical Medicine, Indiana University School of Medicine

Dr. Dexter has been a Biomedical Informatics research scientist at the Regenstrief Institute for more than twenty five years, helping to shape Regenstrief’s information systems for both clinical and research purposes. He served as the Chief Medical Information Officer (CMIO) of Eskenazi Health (formerly Wishard Health Services) for 12 years and IU’s interim and Clinical Research Information Officer (CRIO) for two years. He has coordinated and published a number of randomized clinical decision support trials, including in the New England Journal of Medicine, JAMA, and Annals of Internal Medicine.

As principal investigator of an AHRQ grant, Dr. Dexter spearheaded the implementation of a new clinical decision support platform, natural language processing, i2b2 de-identified query, and other research informatics capacity within Regenstrief Institute.  More recently, he served as Indiana’s co-principal investigator of NIH’s Implementing Genomics in Practice (IGNITE) consortium, which is conducting multiple genomics studies. Dr. Dexter is also the Regenstrief faculty lead for the Merck-Regenstrief collaborative, as well as coordinating with Eskenazi Health leadership on a pilot study using deidentified EHR data to monitor for racial and ethnic disparities.

“Precision health will soon exceed human cognitive capacity by orders of magnitude, ensuring that health care’s future is entwined with computers and software.”

Highlighted Publications

Dexter PR, Schleyer T. Golden opportunities for clinical decision support in an era of team-based healthcare. AMIA Annu Symp Proc. 2022 Feb 21;2021:372-377.

Dexter P, Ong H, Elsey A, Bell G, Walton N, Chung W, Rasmussen L, Hicks K, Owusu-Obeng A, Scott S, Ellis S, Peterson J. Development of a Genomic Data Flow Framework: Results of a Survey Administered to NIH-NHGRI IGNITE and eMERGE Consortia Participants. AMIA Annu Symp Proc. 2020 Mar 4;2019:363-370.

Dexter PR, Grout RW, Embi PJ. Transforming primary medical research knowledge into clinical decision. AMIA Annu Symp Proc. 2021 Jan 25;2020:358-362.

Meng W, Mosesso KM, Lane KA, Roberts AR, Griffith A, Ou W, Dexter PR. An Automated Line-of-Therapy Algorithm for Adults With Metastatic Non-Small Cell Lung Cancer: Validation Study Using Blinded Manual Chart Review. JMIR Med Inform. 2021 Oct 12;9(10):e29017. doi: 10.2196/29017.

Current Research Projects

The Big Ten Electronic Health Record Consortium (Big Ten-EHRC)
(NIH/NCI, PI: Lee) (1999-2021)
The goal of this project is to create a consortium of Cancer Centers that will communicate and coordinate with the NCI and with EHR vendors to facilitate and harmonize rapid implementation of EHR investigative treatment plans for the conduct of NCTN clinical trials. Role: Co-Investigator

Implementing Genomic Medicine through Pragmatic Trials in Diverse and Underserved Populations across Indiana
(UOI NIH-NHGRI, Co-PIs: Skaar & Dexter) (2018-2023)
The goal of this project is to build research infrastructure to recruit for multiple genomics studies related to hypertension, acute and chronic pain, and depression. Role: Co-Principal Investigator for Indiana

Merck Master Collaborative Agreement, Regenstrief Institute, Inc./Merck, Sharp & Dohme Corp. 
(PI: Dexter)
Merck Exploratory Studies Project and project related to constructing a breast cancer repository.
Dr. Dexter serves as the lead faculty member for the collaborative agreement with various clinical researchers leading individual projects. The individual projects he leads focus on data analysis and phenotyping for data pulls.

Regenstrief Health Equities and Disparities Pilot Research Project
The aim of this project is to construct pragmatic methods to monitor for institutional disparities that would warrant further exploration.