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Siu L. Hui, PhD

Siu L. Hui, PhD

  • Distinguished Scientist, Clem McDonald Center for Biomedical Informatics, Regenstrief Institute
  • Scientific Director, Research Services, Regenstrief Institute
  • Professor Emeritus, Department of Biostatistics, Indiana University School of Medicine

Dr. Hui’s research over the past 40+ years has been on the development, improvements, and applications of biostatistical methods in the areas of biomedical and health services research. The methodological research has dealt with the problems of incomplete or irregular measurements over time, performance evaluations and cross-calibrations of instruments for both discrete and continuous measurements in the absence of gold standards, issues in health record linkage, estimation problems in complex sampling, and the reduction of bias inherent in electronic health records.

Areas of application include multiple disease groups, particularly in osteoporosis and bone metabolism, aging and dementia, as well as novel health delivery systems. In addition to observational studies such as epidemiologic and outcomes research on patients in all age ranges, she has also been involved in randomized trials, most of which were conducted in the healthcare setting utilizing the clinical records systems interface.

From 1981 to 2013, Dr. Hui was a professor of biostatistics (Assistant, Associate, and Full) at Indiana University and a Research Scientist at Regenstrief Institute.  Since retiring from IU in 2013, she has been a Distinguished Scientist at Regenstrief Institute.  In 2018, Dr. Hui was appointed as Scientific Director of the Research Data Services.

“Rigorous methodology leads us closer to the truth.”

Highlighted Publications

Hui SL, Walter SD. Estimating the error rates of diagnostic tests. Biometrics. 1980 Mar;36(1):167-71.

Espeland MA, Hui SL. A general approach to analyzing epidemiologic data that contain misclassification errors. Biometrics. 1987 Dec;43(4):1001-12.

McDonald CJ, Hui SL, Zhou XH. Analyzing computer-based decision support systems. Ann Intern Med. 1994 Sep 15;121(6):469. doi: 10.7326/0003-4819-121-6-199409150-00017.

Hui SL, Zhou XH. Evaluation of diagnostic tests without gold standards. Stat Methods Med Res. 1998 Dec;7(4):354-70. doi: 10.1177/096228029800700404.

Ambrosius WT, Hui SL. Cross calibration in longitudinal studies. Stat Med. 2004 Sep 30;23(18):2845-61. doi: 10.1002/sim.1868.

Xu H, Hui SL, Grannis S. Optimal two-phase sampling design for comparing accuracies of two binary classification rules. Stat Med. 2014 Feb 10;33(3):500-13. doi: 10.1002/sim.5946.

Daggy J, Xu H, Hui S, Grannis S. Evaluating latent class models with conditional dependence in record linkage. Stat Med. 2014 Oct 30;33(24):4250-65. doi: 10.1002/sim.6230. Epub 2014 Jun 17.

Kara A, Johnson CS, Nicley A, Niemeier MR, Hui SL. Redesigning inpatient care: Testing the effectiveness of an accountable care team model. J Hosp Med. 2015 Dec;10(12):773-9. doi: 10.1002/jhm.2432. Epub 2015 Aug 19.

Schleyer T, Hui S, Wang J, Zhang Z, Knapp K, Baker J, Chase M, Boggs R, Simpson RJ Jr. Quantifying Unmet Need in Statin-Treated Hyperlipidemia Patients and the Potential Benefit of Further LDL-C Reduction Through an EHR-Based Retrospective Cohort Study. J Manag Care Spec Pharm. 2019 May;25(5):544-554. doi: 10.18553/jmcp.2019.25.5.544.

Khan SH, Manchanda S, Sigua NL, Green E, Mpofu PB, Hui S, Khan BA. Hospital outcomes in non-surgical patients identified at risk for OSA. Heart Lung. 2020 Mar-Apr;49(2):112-116. doi: 10.1016/j.hrtlng.2019.12.001. Epub 2019 Dec 24.

Grout RW, Hui SL, Imler TD, El-Azab S, Baker J, Sands GH, Ateya M, Pike F. Development, validation, and proof-of-concept implementation of a two-year risk prediction model for undiagnosed atrial fibrillation using common electronic health data (UNAFIED). BMC Med Inform Decis Mak. 2021 Apr 3;21(1):112. doi: 10.1186/s12911-021-01482-1.

Weiner M, Dexter PR, Heithoff K, Roberts AR, Liu Z, Griffith A, Hui S, Schelfhout J, Dicpinigaitis P, Doshi I, Weaver JP. Identifying and Characterizing a Chronic Cough Cohort Through Electronic Health Records. Chest. 2021 Jun;159(6):2346-2355. doi: 10.1016/j.chest.2020.12.011.