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Scientists, including Regenstrief research scientist Kurt Kroenke, M.D., have developed a questionnaire to help assess symptoms of manic episodes in patients.

Manic episodes are experienced by individuals living with bipolar disorder, often alongside depressive episodes. While validated tools exist to monitor depression in patients, current tools for monitoring mania are limited.

Research scientists on the team, led by Joseph Cerimele, M.D., MPH, and John C. Fortney, PhD, of the University of Washington, developed the questionnaire, called the PMQ-9, to be similar to the PHQ-9. The PHQ-9 is an existing questionnaire monitoring depression that has been widely adopted in clinical practice. It was created by Dr. Kroenke, who has designed and validated several symptom tracking screeners over his career and served as a mentor and advisor to the PMQ-9 team.

A paper describing the questionnaire’s development, “The Patient Mania Questionnaire (PMQ-9): a Brief Scale for Assessing and Monitoring Manic Symptoms,” is published in the June 2021 edition of the Journal of General Internal Medicine. Additional authors on the paper include Joan Russo PhD, Amy M. Bauer M.D., M.S., Matt Hawrilenko PhD, Jürgen Unützer M.D., MPH, and John C. Fortney PhD of the University of Washington; Jeffrey M. Pyne M.D., of the University of Arkansas for Medical Sciences; and Gregory W. Dalack M.D., of the University of Michigan.

About Kurt Kroenke, M.D., MACP

In addition to his role as a research scientist at Regenstrief Institute, Kurt Kroenke, M.D., MACP, is also director of the Master of Science in Clinical Research program and a professor of medicine at Indiana University School of Medicine.

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