Babar Khan, MD, MS
- Associate Director and Research Scientist, Indiana University Center for Aging Research at Regenstrief Institute
- Professor of Medicine, Indiana University School of Medicine
Dr. Babar Khan’s research is at the intersection of delirium in the intensive care unit (ICU) and the long-term complications experienced by millions of ICU survivors associated with the syndrome. His work is focused on developing innovative interventions to prevent and treat delirium based on an improved understanding of the translational aspects of delirium. He has developed and validated a novel, easy-to-administer tool to score and track delirium severity in the ICU, enabling clinicians anywhere to make better decisions about the brain health of ICU patients. Dr. Khan’s clinical laboratories include both the ICU and a unique post-ICU center known as the Critical Care Recovery Center (CCRC) that treats patients for cognitive, physical, and psychological complications due to their critical illness. In addition to the clinical aspects of patients’ recovery, the center ensures rapid delivery of evidence-based practices and provides a venue to conduct true, ahead-of-the-curve post-ICU research.
Khan SH, Lindroth H, Perkins AJ, Jamil Y, Wang S, Roberts S, Farber M, Rahman O, Gao S, Marcantonio ER, Bosutani M, Machando R, Khan BA. Delirium incidence, duration, and severity in critically ill patients with coronovirus disease 2020. Crit Care Explor. 2020 Nov 25;2 (12): e0290
Twigg HL, Khan SH, Perkins AJ, Roberts S, Sears C, Rahman O, Smith JP, Kapoor R, Farber MO, Ellender T, Carlos G, Gilroy G, Buckley J, Bosslet G, Machado R, Gao S, Khan BA. Mortality Rates in a Diverse Cohort of Mechanically Ventilated Patients With Novel Coronavirus in the Urban Midwest. Crit Care Explor. 2020 Aug;2(8):e0187. doi: 10.1097/CCE.0000000000000187. eCollection 2020 Aug. PubMed PMID: 32903962; PubMed Central PMCID: PMC7447481
Wang S, Lasiter S, Zarzaur B, Campbell T, Boustani MA, Khan BA. Critical Care Recovery Center (CCRC): Can a Geriatric Model of Care Guide Recovery of ICU Survivors? Best practices in mental health. Forthcoming; 12(2).
Khan BA, Fadel WF, Tricker JL, Carlos WG, Farber MO, Hui SL, Campbell NL, Ely EW, Boustani MA. Effectiveness of implementing a wake up and breathe program on sedation and delirium in the ICU. Crit Care Med. 2014 Dec;42(12):e791-5. PubMed PMID: 25402299; PubMed Central PMCID: PMC4311879.
Khan BA, Calvo-Ayala E, Campbell N, Perkins A, Ionescu R, Tricker J, Campbell T, Zawahiri M, Buckley JD, Farber MO, Boustani MA. Clinical decision support system and incidence of delirium in cognitively impaired older adults transferred to intensive care. Am J Crit Care. 2013
Khan BA, Perkins AJ, Campbell NL, Gao S, Farber MO, Wang S, Khan SH, Zarzaur BL, Boustani MA. Pharmacological Management of Delirium in the Intensive Care Unit: A Randomized Pragmatic Clinical Trial. J Am Geriatr Soc. 2019 May;67(5):1057-1065. PubMed PMID: 30681720; PubMed Central PMCID: PMC6492267.
Twigg HL 3rd, Khan SH, Perkins AJ, Roberts S, Sears C, Rahman O, Smith JP, Kapoor R, Farber MO, Ellender T, Carlos G, Gilroy G, Buckley J, Bosslet G, Machado R, Gao S, Khan BA. Mortality Rates in a Diverse Cohort of Mechanically Ventilated Patients With Novel Coronavirus in the Urban Midwest. Crit Care Explor. 2020 Aug;2(8):e0187. doi: 10.1097/CCE.0000000000000187. eCollection 2020 Aug. PubMed PMID: 32903962; PubMed Central PMCID: PMC7447481.
Khan BA, Perkins AJ, Prasad NK, Shekhar A, Campbell NL, Gao S, Wang S, Khan SH, Marcantonio ER, Twigg HL 3rd, Boustani MA. Biomarkers of Delirium Duration and Delirium Severity in the ICU. Crit Care Med. 2020 Mar;48(3):353-361. doi: 10.1097/CCM.0000000000004139. PMID: 31770149; PMCID: PMC7242000.
Boustani MA, Campbell NL, Khan BA, Abernathy G, Zawahiri M, Campbell T, Tricker J, Hui SL, Buckley JD, Perkins AJ, Farber MO, Callahan CM. Enhancing care for hospitalized older adults with cognitive impairment: a randomized controlled trial. J Gen Intern Med. 2012 May;27(5):561-7. PubMed PMID: 22302355; PubMed Central PMCID: PMC3326116.
Current Research Projects
Decreasing Delirium Through Music (DDM) in Critically III Older Adults
(R01 – NIA, PI: Khan) (2019-2024)
This project will measure the effects of music-based interventions on reducing the incidence and impact of delirium in older adults in an intensive care setting.