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Protecting a life’s worth of memories
Changes are inevitable as we grow older. Brain health and safety are critical to healthy aging and quality of life, and while many older adults may experience some mild cognitive decline, others suffer from conditions such as Parkinson’s disease, Alzheimer’s disease, and other forms of dementia. There are few whose lives haven’t been touched in some way by these impairments.
Across the Regenstrief Institute and heavily embedded within the Indiana University Center for Aging Research, investigators are working in both clinical and research settings to better understand how to protect the brain and improve cognitive functioning in older adults – from the partnership with the Sandra Eskenazi Center for Brain Care Innovation, to research studying the effects of medications on the aging brain, as well as interventions for patients with Alzheimer’s and delirium.
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Prevalence of unrecognized cognitive impairment in socially and economically vulnerable older adults is high
Rate is twice as high in African American patients as in White patients INDIANAPOLIS – One of the first studies to investigate the prevalence of unrecognized...
Dr. Boustani: Importance of early detection of cognitive impairment
Protecting a life’s worth of memories Changes are inevitable as we grow older. Brain health and safety are critical to healthy aging and quality of life,…
Dr. Kroenke: Why should traumatic brain injury be a chronic condition?
Protecting a life’s worth of memories Changes are inevitable as we grow older. Brain health and safety are critical to healthy aging and quality of life,…
Recognizing traumatic brain injury as a chronic condition fosters better care over the survivor’s lifetime
INDIANAPOLIS – A commentary published in the Journal of Neurotrauma calls for traumatic brain injury to be recognized as a chronic condition as are diabetes, asthma,...
Preparing for widespread use of biomarkers to diagnose Alzheimer’s disease
Factors for consideration include patient characteristics, test accuracy, ethical issues INDIANAPOLIS – For years many people with Alzheimer’s disease have been diagnosed clinically and confirmed at...
Loneliness worse than smoking, alcoholism, obesity; study suggests primary care clinicians can offer solutions
More than 50 percent of older primary care patients experience loneliness Loneliness is a significant biopsychosocial stressor with a mortality risk comparable to smoking more than...
Overcoming the stigma: study recommends steps to move past barriers of brain health conversations
Approximately four of five primary care clinicians consider themselves on the front lines of brain health. In the U.S., clinicians are the first point of contact...
Drs. Boustani, Unroe and Glober: How interhospital transfers affect patients
Protecting a life’s worth of memories Changes are inevitable as we grow older. Brain health and safety are critical to healthy aging and quality of life,…
Understanding the impact of transferring patients with dementia between hospitals
Benefits may not always outweigh the risks for this vulnerable population. It is common for individuals seeking medical care for symptoms of concern to go to...
Dr. Holden: Tailoring technology to support dementia caregivers
Protecting a life’s worth of memories Changes are inevitable as we grow older. Brain health and safety are critical to healthy aging and quality of life,…
Brain CareNotes telehealth app supports dementia caregivers
Developed with caregiver input, robust, intuitive app will be available for licensing to health systems, health insurance companies, others With the number of Americans living with...
Sachs honored with Excellence in Faculty Mentoring Award
Regenstrief Institute Research Scientist Greg A. Sachs, M.D., was awarded the Indiana University School of Medicine Excellence in Faculty Mentoring award. The award recognizes the...
Regenstrief research scientists participate in national conversation for advancement of aging research
Regenstrief Institute researchers are sharing the stage with other national aging research experts as they participate in the dissemination of scientific advances during the Gerontological Society...
Fowler honored by IUPUI as Research Frontiers Trailblazer
Regenstrief Institute Research Scientist Nicole Fowler, PhD, MHSA, has been honored as a 2023 IUPUI Research Frontiers Trailblazer. The annual award from IUPUI’s vice chancellor for...
Regenstrief researcher elected as fellow of Human Factors and Ergonomics Society
Regenstrief Institute Research Scientist Richard Holden, PhD, M.S., was elected as a Fellow of the Human Factors and Ergonomics Society (HFES). Dr. Holden will be inducted...
CMS Innovation Center visits with Indiana-based dementia care team
Eskenazi, Regenstrief, IU School of Medicine professionals discuss groundbreaking operations A representative of the Centers for Medicare and Medicaid Services (CMS) Innovation Center visited Indianapolis to...
CMS Innovation Center new care, payment model influenced by Eskenazi Health, Regenstrief Institute, IU School of Medicine
Enhanced support for patients with dementia and their unpaid caregivers A team including Eskenazi Health, Indiana University School of Medicine and Regenstrief Institute has helped guide...
Understanding the intersection of Alzheimer’s disease caregiving and the LGBT experience
Insight into disparities can help meet needs of LGBT people with dementia and their caregivers A new study of caregivers of LGBT older adults living with...
Expanding use of brief assessment tools to increase early detection of mild cognitive impairment in primary care
National expert panel issues strategy recommendations for policymakers and payers INDIANAPOLIS – Mild cognitive impairment, which occurs in about one in six individuals in the U.S.,...
Dr. Sprague: Cognitive training can mitigate falls in high-risk older adults
Protecting a life’s worth of memories Changes are inevitable as we grow older. Brain health and safety are critical to healthy aging and quality of life,…
Research to improve quality of stroke care is advancing but gaps exist
Regenstrief research scientist co-authors Stroke’s annual review of advances in quality improvement Every 40 seconds, someone in the U.S. has a stroke. Every 3.5 minutes, someone...
Cognitive training helpful for some but not a panacea for fall prevention
Falls are leading cause of death from injury for older adults in the U.S. One out of four adults, age 65 or older, falls every year...
Regenstrief researcher featured speaker at UsAgainstAlzheimer’s event in Washington, DC
Regenstrief Research Scientist Nicole Fowler, PhD, MHSA, was the featured speaker at an UsAgainstAlzheimer’s event in Washington, D.C. The event was the inaugural Brain Health Bash...
Dr. Babar Khan discusses the importance of negative studies
Protecting a life’s worth of memories Changes are inevitable as we grow older. Brain health and safety are critical to healthy aging and quality of life,…
Another pharmacological approach fails to diminish delirium severity or duration
Commonly prescribed drug classes control blood pressure but don’t prevent ICU-acquired delirium A new study conducted by researchers from Regenstrief Institute and the universities of South...
Factors influencing participation of Black and White Americans in Alzheimer’s disease biomarker research
Regenstrief researcher leads study of barriers to participation and drivers of engagement The use of Alzheimer’s disease (AD) biomarkers such as amyloid and tau levels to...
Digital Detection of Dementia: Using AI to identify undiagnosed dementia
Researchers present protocol for Indianapolis and Miami trials INDIANAPOLIS — Rising to meet the formidable challenge of the timely diagnosis of dementia, research scientists from Regenstrief...
Regenstrief research scientist receives Beeson Emerging Leaders Career Development Award
Prestigious award will support advancing the understanding of role of oxidative stress in cognitive impairment Regenstrief Institute Research Scientist Sikandar Khan, D.O., M.S., has received a...
$11M NIH grant will support evaluation of Alzheimer’s screening tool in primary care settings
Researchers Led by Albert Einstein College of Medicine, Montefiore Health System, Regenstrief Institute, and IU School of Medicine Will Evaluate Test in Urban and Rural Communities...
Treble clef treatment: Music to counter delirium in mechanically ventilated older adults in the ICU
One of first studies to measure actual doses of music Regenstrief Institute, Indiana University School of Medicine and Mayo Clinic researcher-clinicians are conducting a multi-site study...
Regenstrief research scientist 1 of 33 NIA small business mentors
Regenstrief Research Scientist Malaz Boustani, M.D., MPH, was one of 33 mentors for the National Institutes of Health’s National Institute on Aging (NIA) 2022 Healthy Aging...
Regenstrief research scientist to lead American Delirium Society for 2023-24 term
Regenstrief Research Scientist Noll Campbell, PharmD, M.S., has been voted president-elect of the American Delirium Society (ADS) by the board of directors. Dr. Campbell will be...
Dr. Malaz Boustani on stopping the connection between delirium and dementia
With new funding, Dr. Malaz Boustani and co-researchers will study patients who experienced delirium following emergency general surgery to see if a collaborative care model can...
Research team awarded more than $10 million to improve cognitive recovery of post-operative delirium survivors
An interdisciplinary team from University of Wisconsin School of Medicine and Public Health, Regenstrief Institute and Indiana University School of Medicine will evaluate the effectiveness of...
Dr. Noll Campbell on why pharmacists are well-suited for deprescribing
Noll Campbell, PharmD, speaks about the findings from his study about the deprescribing of anticholinergic medications.
Pharmacist-based deprescribing successfully reduced older adults’ exposure to anticholinergic drugs
Anticholinergics, a class of drugs frequently prescribed for depression, urinary incontinence and many other conditions common in older adults, affect the brain by blocking acetylcholine, a...
Majority of stroke patients with depression do not receive mental health treatment
The gap remains unaltered despite changing attitudes toward mental health About one in three stroke survivors will experience depression in the first year after a stroke....
Helping the Helpers: Leveraging information technology to support caregiver medication management for the millions of individuals who live with dementia
Innovative methodology involves caregivers as co-designers not simply informants and includes virtual component More than 21 million people provide unpaid care for millions of people living...
As number of ICU survivors increase, study validates first tool to utilize caregiver input to assess post-ICU syndrome symptoms
Regenstrief and IU researchers developed and tested tool that assesses caregiver as well as patient burden A new study from Regenstrief Institute and Indiana University School...
‘Memory loss is not normal aging’ — Regenstrief scientist highlights challenges of living with dementia
Regenstrief Institute Research Scientist NiCole Keith, PhD, addressed the many challenges faced by the growing number of older Hoosiers living with dementia. She was a guest...
Challenges of deprescribing and minimizing use of anticholinergic medications
Commonly prescribed drug class strongly associated with cognitive impairment in older adults Medications with anticholinergic properties have been consistently associated with a wide range of adverse...
Regenstrief research scientist co-authors national editorial to improve dementia care
Christopher M. Callahan, M.D., a Regenstrief Institute research scientist, co-authored an editorial in the Journal of the American Geriatrics Society (JAGS), “Improving care for dementia: Re-imagining...
EHR alerts go unread, do not lead to deprescribing of medicines linked to dementia
The vast majority of electronic health record (EHR) alerts attempting to reduce the prescribing of high-risk medications linked to dementia in older adults went unread in a study led...
Regenstrief research makes significant contributions to national report on dementia research
Regenstrief Institute Research Scientist Christopher Callahan, M.D., was on the committee that compiled a new report delving into the state of dementia care in America and presented a blueprint for future research to...
National report highlights benefit of collaborative care models for people with dementia
Research and implementation by Regenstrief research scientists cited in report A new report from the National Academies of Sciences, Engineering, and Medicine (National Academies) details the state of dementia care and research in America and...
COVID-19 and the ICU: Regenstrief expert shares experience providing care for patients
Indiana University Center for Aging Research at Regenstrief Institute Associate Director Babar Khan, M.D., M.S., has been treating patients in the intensive care unit (ICU) throughout the COVID-19...
Evaluating the link between medications and dementia: Regenstrief researcher provides consultation
Regenstrief Institute research scientist Noll Campbell, PharmD, M.S., recently contributed to a study that made national headlines and provided more evidence that anticholinergic medications are linked...
Regenstrief research scientist shares ICU experience during Side Effects COVID-19 panel
Regenstrief research scientist Sikandar Khan, D.O., shared his perspective from working in the intensive care unit (ICU) in the midst of the COVID-19 outbreak during a...
Regenstrief research scientists part of leadership for American Delirium Society Digital Meeting
Dr. Noll Campbell, Dr. Babar Khan, and Dr. Sikandar Khan man “mission control” during the meeting. The COVID-19 pandemic has posed many challenges for conference organizers...
Medical panel cites Regenstrief, IU School of Medicine study in recommendations
Findings from a study conducted by Regenstrief Institute and Indiana University School of Medicine research scientists were cited by the U.S. Preventive Services Task Force in...
Regenstrief researcher using bioinformatics expertise in search for Alzheimer’s cure
Regenstrief Institute and Indiana University School of Medicine research scientist Kun Huang, PhD, is leading a team as part of the Indiana University Alzheimer’s disease drug...
Music shows promise in decreasing delirium in critically ill patients
It is common for critically ill patients on life support to develop delirium, a form of acute brain failure for which no effective treatment is known....
Regenstrief researchers leading core of national research incubator
Regenstrief researchers Christopher M. Callahan, M.D., and Alexia M. Torke, M.D., are leading the training core of a major national research incubator with the goal of...
Scientists develop non-invasive method to predict onset of dementia
Screening using EMR data could help with early identification of Alzheimer’s disease risk Information gathered from routine visits to the doctor is enough to accurately predict...
Scientists isolate biomarkers that can identify delirium risk and severity
Opens door to easy, early identification of individuals at risk for delirium complications Regenstrief Institute and Indiana University School of Medicine researchers have identified blood-based biomarkers...
First randomized clinical trial found no harms from dementia screening in primary care
Dementia screening did not induce depression or anxiety in older adults Research scientists at Regenstrief Institute and Indiana University School of Medicine have conducted the first...
Regenstrief podcast The Problem returns, new season highlights Alzheimer’s and dementia
Regenstrief Institute’s podcast, The Problem, returned November 7, 2019 for its second season. This season focuses on a growing health crisis that affects tens of millions...
Regenstrief playing major role in nationwide effort to improve care for dementia patients
Regenstrief research scientists Christopher M. Callahan, M.D., and Alexia M. Torke, M.D., will play a key role in a major nationwide effort to improve healthcare and...
Regenstrief, Mayo Clinic seeking to decrease delirium in older adults in ICU using music
New $1.96 million NIH grant funds research to curb state of confusion linked to dementia Researchers from the Regenstrief Institute and Mayo Clinic are leading the...
Testing effectiveness of a mobile app for assessment of dementia symptoms
Daniel Bateman, M.D., receives federal award to study technological intervention A Regenstrief Institute research scientist is testing a novel mobile app designed to improve care for...
Regenstrief researcher explains passion for implementation science on podcast
Malaz Boustani, M.D., MPH, detailed his career journey and his work in the areas of brain care research and implementation science on the podcast Outcomes Rocket....
Regenstrief scientist explains how class of drugs may be related to dementia
Regenstrief research scientist Noll Campbell, PharmD, M.S., spoke about a common class of drugs and how it affects the brain on an Indianapolis radio show. Dr....
Regenstrief research scientist chosen to lead American Delirium Society
Regenstrief Institute’s Babar Khan, M.D., M.S., a renowned delirium researcher and clinician, has been chosen to lead the American Delirium Society. Dr. Khan has completed extensive...
Researchers develop tool to predict postoperative delirium severity, opening doors to prevention and better care
A new tool seeks to predict the severity of patients’ postoperative delirium and help practitioners more effectively care for patients as they recover from surgery. Currently...
Researchers engage community to help shape future of aging research
Regenstrief hosts second stakeholder summit for aging research Researchers from Regenstrief Institute hosted community leaders, seniors, caregivers and other stakeholders for a discussion about the future...
Boston Globe Highlights Eskenazi Health, Regenstrief Researcher in Article about New Program at Massachusetts General Hospital
The Boston Globe featured an Eskenazi Health program led by Regenstrief Research Scientist Malaz Boustani, M.D.
New Regenstrief studies report drug focused approach insufficient to manage ICU delirium
Clinical trials find changing drugs, deprescribing don’t lower delirium severity, duration
Regenstrief Scientist Provides Education about Alzheimer’s at Indiana Statehouse
Dr. Bateman called Alzheimer’s disease and dementia a public health crisis. He said one in three older adults will die with Alzheimer’s, so the disease will...
Regenstrief Scientist Says African Americans Have Higher Rate of Alzheimer’s Disease, Quoted in USA Today
Daniel Bateman, M.D., says a number of studies show a higher rate of Alzheimer’s disease in African Americans. He told USA Today there are some hypotheses...
Regenstrief Investigator Calls for Medicare Payment for Team-Based Care for Alzheimer’s, Related Dementias
A Regenstrief scientist is calling on the Centers for Medicare and Medicaid Services (CMS) to create access to better care for the 20 million Americans affected...
Prevention and Treatment of ICU Acquired Delirium Requires Personalized Approach
A population heath study from the Regenstrief Institute and Indiana University Center for Aging Research has determined that haloperidol, the drug most commonly used to treat...
First study of benefits and risks of dementia screening for family members of older adults
A majority of individuals with Alzheimer’s receive care from family members, but the effect of early identification of Alzheimer’s by screening on these caregivers has never...
Implications of unmet promise of a miracle drug for Alzheimer’s Disease
Hope looms large for continued improvement in care. Researchers lament the unmet promise of a miracle drug for Alzheimer's Disease (AD) but are heartened by what...
Better education during childhood decreases risk of dementia in African Americans
INDIANAPOLIS – A newly published observational study from the Regenstrief Institute and Indiana University has found that increased levels of education, particularly for those who grew...
Impact of Medicare Annual Wellness Visit on Detection of Cognitive Impairment Is Minimal
INDIANAPOLIS – In the first nationwide study to measure the effect of the Medicare Annual Wellness Visit on early identification of cognitive impairment such as Alzheimer’s...
Controlling blood pressure even when older can prevent dementia in African Americans
INDIANAPOLIS – Controlling blood pressure with any of the commonly prescribed antihypertensive medications can prevent dementia in older African-Americans with hypertension according to a new study...
Many ICU survivors depressed: IU study finds young and African Americans at highest risk
INDIANAPOLIS – Intensive care unit survivors, growing in number as clinicians and medical technology save more lives, are psychologically as well as medically fragile. The first...
IU and Regenstrief studying decreasing dementia after delirium for older ICU survivors
Researchers from the Indiana University Center for Aging Research and the Regenstrief Institute are developing and testing the nation’s first program to deliver via telemedicine specially...
New IU collaborative care model focuses on full recovery of those injured after age 50
INDIANAPOLIS – An estimated 1.4 million Americans over age 50 are hospitalized for severe injuries annually–most often due to motor vehicle crashes or falls. The majority...
IU Center for Aging Research develops novel ICU delirium severity assessment tool
INDIANAPOLIS — Millions of intensive care unit patients in the United States experience delirium, an acute brain failure resulting in confusion and long-term memory problems. Researchers...
New $3.2 million NIH grant supports nation’s first mobile post-ICU recovery program
INDIANAPOLIS — Two million of the five million Americans admitted to intensive care units annually have or develop acute respiratory failure, predisposing them to long-term cognitive,...
Rapidly meeting the mental health needs of older adults
INDIANAPOLIS — Nearly 20 percent of older Americans experience depression and the highest rate of suicide is among older adult Caucasian males. Despite the anticipated growth...
Older adults with obesity less responsive to memory training than those with lower BMIs
INDIANAPOLIS – In the first study to compare the results of cognitive training by body mass index (BMI) category, scientists from the Indiana University Center for...
Study finds occupational therapy unable to delay Alzheimer’s patients’ functional decline
INDIANAPOLIS – In the first study to investigate whether two years of in-home occupational therapy might help those with Alzheimer’s disease delay the loss of their...